233 papers
Molecular biology explores the tiny machinery inside living cells, revealing how genetic instructions are read, copied, and turned into the proteins that keep us alive. This field acts as a bridge between the static code of DNA and the dynamic processes that drive growth, disease, and life itself, offering insights into everything from cellular repair to the development of new medicines.
On Gist.Science, we track every new preprint uploaded to bioRxiv in this category to make these complex discoveries accessible to everyone. Our team processes each submission to provide both clear, plain-language explanations and detailed technical summaries, ensuring you can grasp the core findings without getting lost in dense academic jargon.
Below are the latest molecular biology papers freshly processed from bioRxiv, ready for you to explore and understand.
This study demonstrates that the histone chaperone FACT is essential for maintaining active promoter topology by preserving nucleosome integrity to prevent the invasion of chromatin-binding factors, thereby ensuring both local nanoscale domains and large-scale chromatin architecture.
This paper introduces the amyloid packing difference (APD), a metric that quantifies structural variations between amyloid filaments based on unique cross-beta interactions and side chain orientations, demonstrating its ability to effectively distinguish disease-associated protofilament folds of proteins like alpha-synuclein and tau through clustering and specific value thresholds.
This study identifies PARP6 as a cardioprotective enzyme that suppresses cardiac fibrosis by ADP-ribosylating vimentin to inhibit RhoA-mediated actin stress fiber formation and myofibroblast activation.
This study characterizes the structural and functional dynamics of the *Bacteroides thetaiotaomicron* dextran utilisome, revealing its multi-component architecture, substrate binding mechanisms, and conformational states through integrated X-ray crystallography, calorimetry, and cryo-EM analyses.
This study identifies a novel, evolutionarily primordial RAB5 binding site on the VPS15 solenoid of human VPS34 complex II, revealing that the expansion from a single ancestral binding site to two distinct sites likely enhanced membrane association and complex activity to support the development of complex eukaryotic endocytic systems.
A cross-sectional study conducted in Western Oromia, Ethiopia, between January and December 2022, revealed a 21.1% overall prevalence of pneumonic pasteurellosis-causing bacteria (*Pasteurella multocida*, *Mannheimia haemolytica*, and *Bibersteinia trehalosi*) in sheep, with significantly higher infection rates observed in clinically ill and younger animals, underscoring the need for targeted management and molecular surveillance.
This paper presents a multi-modal AI/ML framework utilizing Graph Convolutional Networks to integrate global and local protein descriptors, thereby improving the accuracy of protein conformation selection and prediction for drug discovery applications.
This study demonstrates that the biophysical properties of charge and hydrophobicity, along with cooperative interactions between transcription factors, critically govern the efficiency and specificity of SOX2 and ESRRB target search dynamics within the nucleus, revealing that ESRRB relies heavily on SOX2-mediated confinement to locate its binding sites.
This study identifies CNOT6 as an essential post-transcriptional regulator that ensures healthy postnatal growth and metabolic transition by promoting the decay of Fgf21 mRNA, thereby preventing excessive FGF21 expression that would otherwise suppress anabolic metabolism and cause severe growth retardation.
This chapter reviews computational strategies for exploring RNA conformational ensembles, highlighting current limitations in sampling and force-field accuracy while discussing case studies and emerging directions like machine learning and experimental integration to enhance predictive power.